1Cademy - A fatal case of COVID-19 in a patient with common variable immunodeficiency

A fatal case of COVID-19 in a patient with common variable immunodeficiency

Specific case study detailing the COVID-19 treatment process of a 42 y/o man with CVID, chronic asthma, and severe obesity
Patient had not received IVIG treatment in 6 months due to insurance complications
In May patient noted COVID-19 symptoms and received COVID-19 testing, which came back positive
Was admitted to community hospital with fevers and worsening dyspnea, which revealed multifocal pneumonia
Patient was intubated and condition worsened, causing patient to be transferred to distant hospital which could provide higher level of care
When transferred immunoglobulin levels were measured and all Ig levels were extremely low with undetectable IgM
Patient then received repeat and increasing treatments of IVIG (day 9 was 400 mg/kg to day 17 with 1 g/kg) and condition improved drastically as well as IgG serum concentration increases
On day 20 patients condition worsened and redeveloped a fever and on day 30 patient suffered cardiac arrest
It is being hypothesized CVID has the possibility to inhibit antibody development for COVID-19 antibodies in patients due to low levels of serum immunoglobulin

6 years ago

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