 Black bars: number of patients with available results, grey bars: number of patients with positive culture, solid line: percentage of patients with a positive culture, dashed line: logarithmic regression curve.

University of South Florida

According to the authors, COVID-19 poses two major challenges to physicians: therapeutic management of patients, and the rapid spread of the disease in the population through contagious individuals. The researchers have provided evidence of  a beneficial effect of co-administration of hydroxychloroquine with azithromycin in the treatment of COVID-19 and its potential effectiveness in the early reduction of contagiousness.

Discussion: Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Gautret, P., Lagier, J., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., et al.  (2020). Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study. Travel Medicine and Infectious Disease, 34(SI), 101663. doi:10.1016/j.tmaid.2020.101663
https://www.sciencedirect.com/science/article/pii/S1477893920301319

Clinical and microbiological effect of a combination of Hydroxychloroquine and Azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

 This is a descriptive pilot study conducted in only 80 patients with relatively mild clinical presentation and the researchers did not attempt an analytic approach to account for possible confounding factors including notably the severity of illness. Such an approach is currently planned in a larger set of patients under treatment at the institute in which this study took place.

Limitations: Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Black bars: number of patients with available results, grey bars: number of patients with PCR Ct value < 34, solid line: percentage of patients with PCR Ct value < 34, dashed line: logarithmic regression curve.

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